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UTHSC Team Receives $2.19 Million to Study Neurotoxicity of Commonly-used Chemical Solvent

A team of University of Tennessee Health Science Center researchers has been awarded $2.19 million from the National Institute of Environmental Health Sciences for their investigation of the neurotoxic effects of toluene, a common chemical found in many household products.  

Dr. Alex Dopico

Alex M. Dopico, MD, Van Vleet Chair of Excellence and professor in the Department of Pharmacology, Addiction Science, and Toxicology (PHAST) in the College of Medicine, and Anna N. Bukiya, PhD, professor in the same department, are principal investigators on the award. Jeff Steketee, PhD, also a professor in the PHAST Department and chair of the Institutional Animal Care and Use Committee, is a co-investigator.

Toluene reaches the brain through inhalation. Intoxication with toluene, whether accidental or following recreational use (e.g., “glue sniffing”), leads to dizziness, blurred vision and even neurological deficits with catastrophic outcomes, including death. A reduction in blood flow to the brain is thought to contribute to these toxic effects, but how and why toluene exposure affects the brain circulation is not known.  

Dr. Anna Bukiya

The team hypothesizes that toluene reduces the activity of a protein (the BK channel) located in the cerebral artery muscle cells, causing the brain arteries to constrict upon exposure. Performing tests at the molecular level using computational methods, and in vitro and in vivo evaluation of BK channel function in animal models, the team aims to identify the specific mechanism and site of action in BK channels that makes cerebral arteries constrict in the presence of toluene. Their tests will include delivering new selective drug therapies for early intervention in toluene-induced brain ischemia.

The project, titled “Ionic mechanisms of toluene cerebrovascular actions”, is being funded over five years.

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    https://gitea.goldendeliverer.com/ralphverjus656/3645rocketplay-account-bonus-code-australia/wiki/All-Rocketplay-Casino-No-Deposit-Bonus-Codes-New-%26-Existing-Players-May-2026 gitea.goldendeliverer.com

    https://git.automathon.org/isobelgebhardt git.automathon.org

    http://gitea.jb1000.com:88/nevilletudawal gitea.jb1000.com

    https://mycrewdate.com/@samiraoshane8 mycrewdate.com

    https://mapnova.com.co/employer/rocketplay-au-promo-code-200-off-sitewide-in-may-2026/ mapnova.com.co

    References:
    nas.zearon.com

  7. Вывод из запоя в Сочи требуется, когда человек не может самостоятельно прекратить употребление алкоголя, испытывает похмелья, признаки ломки, тревогу, бессонницу, рвоту, сильную слабость или резкое ухудшение самочувствие. Даже если запой длится несколько дней, риск осложнений остается высокий: страдают системы организма, печень, сердце, сосуды, нервная система, психика и общее состояние здоровья.
    Получить больше информации – [url=https://vivod-iz-zapoya-sochi23.ru/]вывод из запоя капельница сочи[/url]

  8. Вывод из запоя на дому в Казани удобен, когда близкий человек не готов ехать в клинику, плохо переносит дорогу или находится в состоянии сильной слабости. Врач приезжает на дому, сохраняет анонимность, спокойно объясняет процесс и начинает лечение только после осмотра и согласия пациента. Вызов врача на дому особенно важен, если муж, отец, брат, мама или другой близкий уже не может перестать пить и нуждается в срочной помощи.
    Разобраться лучше – вывод из запоя круглосуточно в казани

  9. после вашего обращения наш врач приезжает по указанному адресу с медработниками в гражданской форме и на машине без опознавательных символов, проводит осмотр, собирает историю болезни (анамнез).
    Исследовать вопрос подробнее – http://vyvod-is-zapoya-sochi23.ru

  10. Вывод из запоя — это только первый шаг в лечении алкогольной зависимости. Без последующей терапии риск рецидива очень высок. Наш наркологический центр предлагает полный курс лечения алкоголизма, включая кодирование и психотерапию. Кодирование на дому проводится различными методами: уколом (Торпедо, Эспераль, Налтрексон, Аквилонг), медикаментозным вшиванием (дисульфирам, Вивитрол), гипнозом по Довженко, а также двойным блоком. Каждый метод подбирается врачом индивидуально, с согласия пациента и при отсутствии противопоказаний. Опытный нарколог объяснит, какая кодировка подойдёт именно вам, учитывая стаж и форму зависимости.
    Получить дополнительную информацию – narkolog-na-dom-balashiha13-3.ru/

  11. Лечение зависимости от алкоголя у мужчин в стационаре Балашихи. Мы предлагаем индивидуальный подход к лечению мужчин, учитывая все особенности организма.
    Получить больше информации – вывод из запоя клиника

  12. Сегодня легко вызвать нарколога на дом в Балашиху круглосуточно, просто позвонив по единому телефону нашего специализированного центра в любое время суток, любой день (даже в выходные и праздники). Наркологическая помощь может понадобиться в любое время дня и ночи, поэтому клиника доктора Исаева оказывает широкий спектр услуг, в том числе в домашних условиях, 24/7. Алкогольная зависимость и наркомания — серьёзные заболевания, требующие немедленного квалифицированного вмешательства. Вывод из запоя и лечение алкоголизма на дому или в стационаре начинается с полного осмотра врача-нарколога, диагностики состояния и назначения индивидуальной схемы терапии. Мы гарантируем полную анонимность и конфиденциальность — данные пациента обрабатываются строго в соответствии с политикой обработки персональных данных. Наши специалисты имеют многолетний опыт работы с зависимыми людьми, используют современные и безопасные препараты, позволяющие быстро восстановить организм после отравления алкоголем или наркотиками. Лечение алкоголизма — это процесс, который требует времени и комплексного подхода, но первый шаг к выздоровлению можно сделать уже сегодня. Очень важно не откладывать обращение, ведь каждый день запоя усугубляет состояние здоровья и повышает риск тяжелых осложнений. Вывод из запоя и детоксикация — первый этап на пути к трезвости, и от качества лечения зависит дальнейшая ремиссия.
    Узнать больше – http://narkolog-na-dom-balashiha13-1.ru

  13. Детоксикация наркоманов в Москве — это первый и самый важный шаг на пути к полному избавлению от наркотической зависимости. В наркологической клинике «Частный Медик 24» детоксикация от наркотиков проводится строго в условиях стационара, с применением современных медицинских методик и под круглосуточным контролем опытных врачей. Лечение наркомании требует комплексного подхода, и детоксикация позволяет безопасно очистить организм от токсичных продуктов распада психоактивных веществ, снять острые симптомы абстиненции и подготовить пациента к дальнейшей реабилитации. Мы работаем круглосуточно, чтобы каждый житель Москвы и области мог получить экстренную наркологическую помощь именно тогда, когда она жизненно необходима. Хочу подчеркнуть: наша главная задача — не просто снять ломку, а сделать первый шаг к полноценной жизни без наркотиков. Использование качественных медикаментов и проверенных схем детоксикации является основой успешного лечения.
    Получить дополнительную информацию – детоксикация после наркотиков москва

  14. выездная наркологическая служба оперативно приедет по указанному адресу, имея при себе все необходимое оборудование и медикаменты, в том числе для оказания неотложной помощи.
    Подробнее тут – анонимный вывод из запоя сочи

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