August 10, 2022
11 11 11 AM
Rosario Dawson Says ‘I Love You’ to Nnamdi Okafor Following Corey Booker Split
Heather Rae El Moussa Gets ‘Flutters’ Over New Ultrasound of Baby Boy
Ukraine war: Blasts rock Russian airbase in annexed Crimea
Lizzie McGuire’s Jake Thomas Relates to One Scene in Jordan Peele’s Nope
Jason and Brett Oppenheim Tease Heather Rae El Moussa’s Future on Selling Sunset
Russia using Zaporizhzhia nuclear power plant as army base – Ukraine
Camila Coelho Gives Birth to Her First Baby
Israel-Gaza: Hopes as Gaza ceasefire comes into effect
Barcelona transfer news: Latest on Alonso, Depay, player signings, loans & deals in summer window 2022
Katie Holmes and Bobby Wooten III Are All Smiles on Romantic NYC Stroll
Latest Post
Rosario Dawson Says ‘I Love You’ to Nnamdi Okafor Following Corey Booker Split Heather Rae El Moussa Gets ‘Flutters’ Over New Ultrasound of Baby Boy Ukraine war: Blasts rock Russian airbase in annexed Crimea Lizzie McGuire’s Jake Thomas Relates to One Scene in Jordan Peele’s Nope Jason and Brett Oppenheim Tease Heather Rae El Moussa’s Future on Selling Sunset Russia using Zaporizhzhia nuclear power plant as army base – Ukraine Camila Coelho Gives Birth to Her First Baby Israel-Gaza: Hopes as Gaza ceasefire comes into effect Barcelona transfer news: Latest on Alonso, Depay, player signings, loans & deals in summer window 2022 Katie Holmes and Bobby Wooten III Are All Smiles on Romantic NYC Stroll

UTHSC Team Receives $2.19 Million to Study Neurotoxicity of Commonly-used Chemical Solvent

A team of University of Tennessee Health Science Center researchers has been awarded $2.19 million from the National Institute of Environmental Health Sciences for their investigation of the neurotoxic effects of toluene, a common chemical found in many household products.  

Dr. Alex Dopico

Alex M. Dopico, MD, Van Vleet Chair of Excellence and professor in the Department of Pharmacology, Addiction Science, and Toxicology (PHAST) in the College of Medicine, and Anna N. Bukiya, PhD, professor in the same department, are principal investigators on the award. Jeff Steketee, PhD, also a professor in the PHAST Department and chair of the Institutional Animal Care and Use Committee, is a co-investigator.

Toluene reaches the brain through inhalation. Intoxication with toluene, whether accidental or following recreational use (e.g., “glue sniffing”), leads to dizziness, blurred vision and even neurological deficits with catastrophic outcomes, including death. A reduction in blood flow to the brain is thought to contribute to these toxic effects, but how and why toluene exposure affects the brain circulation is not known.  

Dr. Anna Bukiya

The team hypothesizes that toluene reduces the activity of a protein (the BK channel) located in the cerebral artery muscle cells, causing the brain arteries to constrict upon exposure. Performing tests at the molecular level using computational methods, and in vitro and in vivo evaluation of BK channel function in animal models, the team aims to identify the specific mechanism and site of action in BK channels that makes cerebral arteries constrict in the presence of toluene. Their tests will include delivering new selective drug therapies for early intervention in toluene-induced brain ischemia.

The project, titled “Ionic mechanisms of toluene cerebrovascular actions”, is being funded over five years.

Leave a Reply

Your email address will not be published.