The new research, described online Oct. 26 in the American Journal of Respiratory and Critical Care Medicine, is a secondary study of a larger Johns Hopkins-led project, the CLEAN AIR study. The CLEAN AIR study, which investigated the effects of indoor air pollution on COPD, found that people with COPD experienced improved symptoms after using portable air purifiers indoors.
“We’ve seen that air pollution in the home, where people spend a majority of their time, contributes to impairments in respiratory health. We hypothesized this pollution is a big driver of cardiovascular disease and cardiac events in people with COPD,” says lead author Sarath Raju, M.D., M.P.H., an assistant professor of medicine who specializes in obstructive lung diseases at the Johns Hopkins University School of Medicine.
Researchers recruited 85 men and women from the original CLEAN AIR study, who were adults (average age 65) with COPD. The participants lived primarily in the Baltimore area.
First, researchers had trained technicians take air samples of indoor particulate matter of varying sizes from participants’ homes. These indoor air pollutants are composed of such things as mold and pet dander. One of the tiniest kinds of particulate matter, PM 2.5 — smaller than the diameter of a human hair — can be detrimental to respiratory and heart health by infiltrating the bloodstream through the lungs and causing inflammation. The level of PM 2.5 indoors should stay at or below 12 micrograms per cubic foot for the air to be considered healthy to breathe. Participants’ homes had an average of 13.8 micrograms per cubic foot of PM 2.5.
Then, 46 randomized participants received two portable air cleaners with HEPA and carbon filters to use at home; the other participants received placebo air cleaners that circulated air but had the filters removed.
Researchers tracked and measured several indicators of lung and heart health at the one week, three-month and six-month periods of the study using standard clinical tests, such as blood pressure and heart ultrasounds (echocardiograms). Additionally, participants wore heart rate monitors for 24 hours during each clinical testing period, to assess heart rate variability.
At the end of the experiment, all 46 participants with active HEPA and carbon filters had improved markers of heart health, specifically a 25% increase in heart rate variability. Participants without the active filters saw no increase.
Heart rate variability, or HRV, is a common measure of heart health calculated using other statistical variables, such as the standard deviation between heart beats. HRV consists of changes in the time intervals between consecutive heart beats. A healthy heart is constantly adjusting its rate to meet the body’s physical demands, and as such, has a higher heart rate variability.
Among 20 participants who used the air purifiers with active filters 100% of the time while at home, there was also a 105.7% increase in a heart health variability measure called the root mean square of successive differences between normal heartbeats, or RMSSD, which is associated with improved heart fitness.
The team also looked at the effects of ultrafine particles in the homes. These particles, smaller than a thousandth of a millimeter or one micron, are able to travel to the deepest part of the lungs when inhaled, and can even cross into the bloodstream.
In their evaluation of 29 participants and their homes, the researchers uncovered a correlation between an increase in ultrafine particles and poorer heart health markers, such as lower heart rate variability. The team says more research must be done in this area.
“Ultrafine particles might be the most potent particles in terms of health consequences,” says study author Meredith McCormack, M.D., M.H.S., associate professor of medicine at the Johns Hopkins University School of Medicine and director of the BREATHE Center (Bridging Research, Lung Health and the Environment). “These particles and other indoor air pollutants can cause systemic inflammation in susceptible patients like those with COPD. Our study shows there’s a negative impact on cardiovascular health, as well.”
“In the future, air cleaners may be something to recommend to patients along with medications, but also can be part of a larger discussion about the importance of home environments,” says Raju.
Other researchers involved in the study include Han Woo, Ashraf Fawzy, Chen Liu, Nirupama Putcha, Aparna Balasubramanian, Cheng Ting Lin, Ronald Berger and Nadia Hansel of the Johns Hopkins University School of Medicine; Kirsten Koehler and Roger Peng of Johns Hopkins Bloomberg School of Public Health; Chantel Lemoine of the University of Pittsburgh Medical Center; and Jennifer Wineke of the University of Maryland Medical Center.
This research was funded by NIH/NIEHS grants (R01ES022607, R21ES025840 and F32ES029786), a NHLBI grant (K12HL143957 and K23HL164151) and a Johns Hopkins University Catalyst Award.
The authors report no conflict of interest.
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Die ersten beiden Universitäten im Kurfürstentum
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Andreas Löhle knackt laufend die Automaten. Die Polizei hat
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Die seit dem Frühjahr 1917 steigende Zahl der Streiks und Massenproteste,
die durch die russische Revolution weiter angefacht werden, ist ein sichtbarer Ausdruck der wachsenden Kriegsmüdigkeit
und des Wunsches nach Frieden. Die Neuapostolische Kirche hat im
Laufe ihrer Geschichte Spaltungen und Abtrennungen erlebt.
05. Dezember: In Bangladesch wird Präsident Hossain Mohammad Ershad gestürzt.
Demgegenüber engagierte sich eine Gruppe von Remigranten um Brandt und Ernst
Reuter, vor allem von West-Berlin aus, für eine stärkere Westorientierung der SPD.
Matthias Erzberger wurde als Sohn des Schneiders und nebenberuflichen Postboten Josef
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Er beendete den Grand Prix vor seinem Teamkollegen Piquet.
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Kurz nacheinander kaufte er den Baugrund für alle
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↑ Auf Basis der Überlagerung vom Stadtplan mit dem
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und dem gegenüberstehenden fünfgeschossigen Wohnhauskarree zu Am Nussbaum,
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⚭ (I) 1621 Prinzessin Elisabeth Sophie von Schleswig-Holstein-Gottorf (1599-1627), Tochter des Herzogs Johann Adolf von Schleswig-Holstein-Gottorf (1575-1616), ⚭ (II)
1633 Gräfin Katharina von Oldenburg (1582-1644), Tochter des Grafen Johann XVI.
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2015 Geboren als Martha Bernstein am 10. Vergangene Woche
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der münsterschen Bürgerschaft in den Kreis der Erbmänner nachträglich aufgenommen worden wäre.
Große Chemiestandorte sind in Frankreich, Spanien, Portugal und Italien angesiedelt.
Nach seiner Entlassung aus dem städtischen Gesundheitswesen Berlins eröffnete
er eine Privat- und Kassenpraxis an seiner Wohnadresse
in Alt-Moabit 86c, wo er und seine Ehefrau von 1933 bis 1941 lebten. 23.3.1942 Im April und Juni 1938 wurden reichsweit mehr als 10.000 Menschen im Rahmen der Aktion „Arbeitsscheu Reich“ in Konzentrationslager
deportiert, darunter Robert Raths. Schneider, Schuster und andere Handwerker begleiteten die Armee.
Da jeder Reiter sein eigenes Pferd besaß, für das er allein verantwortlich
war, entstand schnell eine Beziehung zwischen Mensch und Tier.
Erst nach der Saison äußerte Schumacher, dass ihn allein der „Anblick dieses Bremsfallschirms“, wie er die Seitenwülste nannte, abgestoßen habe.
Sie bestand aus drei Schiffen im Stil einer Basilika, deren Dächer leicht
nach außen entwässert werden konnten. Während Papa Til Ärger mit seinem
Hotel-Projekt am Tegernsee hat, schwebt Tochter Luna Schweiger
auf Wolken sieben. http://mundanam.com/ Ihre Tochter Henriette Käthe hatte
1939 Deutschland verlassen und in England den ebenfalls emigrierten Erich
Hirsch (später Eric James Higgins) geheiratet. Moderiert wird die
Sendung seit ihrer Gründung im Jahr 1996 vom Moderator Uwe Madel.
August 1942 alleine nach Auschwitz deportiert.
Trash-TV-Fans in Deutschland hatten den Montagabend sehnlichst herbeigesehnt, denn
endlich ging die neue Staffel von “Promis unter Palmen”
bei Sat.1 an den Start. Zu Beginn des Kaiserreichs zählten bereits fast
zwei Drittel der deutschen Juden zur wirtschaftlichen und kulturellen Elite des Landes;
die religiösen Bindungen und Lebensformen der Vergangenheit waren ihnen fern gerückt.
Wie viel Geld er hat kann also nur geschätzt werden. Reisen regelmäßig des Inkognitos und nutzte es gezielt zur Steigerung seines Ansehens wie auch als wesentliches Instrument seiner Herrschaft.
Zur Umfahrung der Fußgängerzone Kaiserstraße, die während der Ladenöffnungszeiten für Fahrradfahrer gesperrt ist, wurden die
Cityrouten Nord und Süd eingerichtet, die, wie auch andere Straßen im Radroutennetz,
teilweise als Fahrradstraßen ausgewiesen wurden. So adoptierte
er Ende des vergangenen Jahres den Studenten Kevin Feucht (27).
1217 starb auch Philipp. Bei so viel Glanz und Glamour geraten selbst seine prominenten Gäste Schlagerstar Markus Becker,
„No Angels“-Sängerin Jessica Wahls und Ex-„Deutschland sucht den Superstar“-Kandidatin Lisa Bund ins Staunen. Deutsche Gesellschaft für Ordenskunde e.
1921 ließ Gottfried Gompertz für sich und seine Familie in Bockum
das Haus Wilhelmshofallee 190 errichten, um 1930 dann auch das danebengelegene Haus Wilhelmshofallee 182, das später vermietet wurde.
↑ Maria Fritsche: Österreichische Opfer der NS-Militärgerichtsbarkeit.
Inklusive Unterarten treten in Österreich 3.428 Elementar-Gefäßpflanzen-Taxa auf,
dies sind beispielsweise um rund 300 Elementar-Taxa mehr als im flächenmäßig ungefähr viereinviertelmal so großen Nachbarland
Deutschland. Aufgrund militärstrategischer Interessen der französischen Regierung wurde
die Frage zur Weiterführung der in Thionville endenden Bahn aber dahingehend entschieden, nach Luxemburg weiter zu bauen. Alle Fragen hatten einen regionalen Bezug aus den 16 Bundesländern von Deutschland.
Als erste Gliederungsreform seit der Gründung der Bundesrepublik wurden am
25. http://www.rebelscon.com/viewtopic.php?id=4207061
1940: Ein Luftangriff der britischen Royal Air Force im Zweiten Weltkrieg auf Hamburg als Antwort auf die Bombardierung von Coventry
zwei Tage zuvor fordert 233 Tote. Daneben berichtet Sueton von der Inszenierung des Leichenbegängnisses, welche die Plebs aufwühlte: Vor
der Rednertribüne auf dem Forum Romanum sei ein verkleinertes Modell
des von Caesar errichteten Tempels der Venus Genetrix aufgestellt
worden, von der Caesar angeblich abstammte; darin wurde die blutgetränkte Kleidung des Diktators gezeigt;
die Errichtung des Scheiterhaufens auf dem Marsfeld habe mehrere Tage in Anspruch genommen, da allzu viele Menschen noch Totengaben darauf legen wollten. Er
konnte insgesamt 18 der 22 Embryonen zu guten Preisen verauktionieren. Landstuhl am 7.1.1743 Magdalena
ENGDLERIN aus Queidersbach. Ein weiterer Sohn, Alhard IV.,
verheiratet mit Gertrud von Bischopinck, erbte 1603/1605 von seiner Schwester Margaretha, der Witwe
des Cord von Steveninck, Haus Möllenbeck (heute: Wolbeck).
Die Siebenten-Tags-Adventisten gibt es in Deutschland seit
1875. 1917: Zur Mittagszeit erscheint die Jungfrau Maria im portugiesischen Fátima zum letzten Mal
den drei Schäferkindern Jacinta Marto, Francisco Marto und Lúcia dos
Santos. Zwar kann man auch hier versuchen, nichts dem Zufall zu überlassen und den Wuchs,
die Blüte und vor allem die Ausrichtung der Pflanzen zu kontrollieren. Der && Operator ist ein Sequenzpunkt: Alle Nebenwirkungen des linken Operanden müssen bewertet worden sein, bevor die
Nebenwirkungen des rechten Operanden ausgewertet
werden. Dies war der Grund dafür, dass er nach dem Tod Friedrich Wilhelms II.
↑ Sonja Žitko: Die dem Erzherzog Johann von Österreich gewidmeten Denkmäler in Slowenien. hier
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